2024

  1. Liao JZ*, Chung HL*, Shih C., Wong KKL., Dutta D, Nil Z, Burns CG, Kanca O, Park YJ, Zuo Z, Marcogliese PC, Sew K, Bellen HJ# and Verheyen EM#. (2024) Cdk8/CDK19 promotes mitochondrial fission through Drp1 phosphorylation and can phenotypically suppress pink1 deficiency in Drosophila. Nature Communications,15, 3326. PMID: 38637532 *Contributed equally; #Co-corresponding
  2. Tanaka T, Chung HL. (2024) Exploiting fly models to investigate rare human neurological disorders. Neural Regeneration Research DOI: 0.4103/NRR.NRR-D-23-01847

2023

  1. Chung HL*,#, Ye Q*, Park YJ, Zuo Z, Kanca O, Tattikota SG, Lanza IR, Oglesbee D, Perrimon N, Lee HK#, Bellen HJ# (2023). Very-long-chain fatty acids induce glial-derived sphingosine-1-phosphate synthesis, secretion, and neuroinflammation. Cell metabolism.PMID: 37084732 *Contributed equally; #Co-corresponding
  2. Ma M*, Zhang X*, Zheng Y, Lu S, Pan X, Mao X, Pan H, Chung HL, Wang H, Guo H#, Bellen HJ#(2023). The fly homolog of SUPT16H, a gene associated with neurodevelopmental disorders, is required in a cell-autonomous fashion for cell survival. Human Molecular Genetics. PMID: 36255738 *Contributed equally; #Co-corresponding

2022

  1. Chung HL, Rump P, Glassford MR, Fatih J, Basal A, Marcogliese PC, Rapp M, Fock JM, Kamsteeg E, Lupski JR, Larson A, Haninbal MC, Bellen HJ#, Harel T# (2022). De novovariants in EMC1 lead to neurodevelopmental delay and cerebellar degeneration and affect glial function in Drosophila. Human Molecular Genetics. PMID: 35234901 #Co-corresponding
  2. Lu S, Hernan R, Marcogliese PC, Huang Y, Gertler TS, Akcaboy M, Liu S, Chung HL, Pan X, Sun X, Oguz M, Oztoprak U, de Baaij JHF, Ivanisevic J, McGinnis E, Sacoto MJG, Chung WK#, Bellen HJ# (2022) Loss of function variants in TIAM1 are associated with developmental delay, intellectual disability and seizures. American Journal of Human Genetics: 25;S0002-9297(22)00051-9. PMID: 35240055 #Co-corresponding
  3. Marcogliese PC*, Deal SM*, Andrews J*, Harnish JM*, Bhavana VH, Graves HK, Jangnam S, Luo Xi, Liu N, Bei D, Hull B, Lee P, Pan H, Brady C, Chao H, Chung HL, Haelterman NA, Kanca O, Manivannan SN, Rosetti LZ, Gerard A, Schwaibold EMC, Guerrini R, Vetro A, England E, Murali CN, Barakat TS, Dooren MF, Wilke M, Slegtenhorst MV, Sabatier I, Chatron N, Brownstein CA, Madden JA, Agrawal PB, Keller R, Pavinato L, Brusco A, Rosenfeld JA, Marom R, Wangler MF#, Yamamoto S# (2022) Drosophila functional screening of de novo variants in autism uncovers deleterious variants and facilitates the discovery of rare neurodevelopmental diseases. Cell reports: 15;38(11):110517. PMID: 35294868 *Contributed equally; #Co-corresponding
  4. Marcogliese PC*,#, Dutta D*, Sinha-Ray S, Dang NDP, Zuo Z, Wang Y, Lu D, Fazal F, Ravenscroft TA, Chung HL, Kanca O, Wan J, Douine ED, Pena LDM, Yamamoto S, Nelson SF, Might M, Meyer KC, Yeo NC, Bellen HJ# (2022). Loss of IRF2BPL impairs neuronal maintenance through excess Wnt signaling. Science Advances: 21;8(3):eabl5613. PMID: 35044823 *Contributed equally; #Co-corresponding

2021

  1. Manivannan SN, Roovers J, Smal N, Meyers CT, Turkdogan D, Roelens F, Kanca O, Chung HL, Scholz T, Herrmann K, Bierhals T, Mefford H, de Jonghe P, Yamamoto S, Weckhuysen S, Bellen HJ (2021) De novo FZR1 loss-of-function variants cause developmental and epileptic encephalopathies including Myoclonic Atonic Epilepsy. Brain. PMID: 34788397
  2. Manor J, Chung HL, Bhagwat P, Wangle MF (2021) ABCD1 and X-linked adrenoleukodystrophy: A disease with a markedly variable phenotype showing conserved neurobiology in animal models. Journal of Neuroscience Research. review article. PMID: 34716609

2020

  1. Park YJ, Kim S, Shim HP, Park JH, Lee G, Kim TY, Jo MC, Kwon AY, Lee M, Chung HL, Bellen HJ, Kwon SH, Jeon SH (2020) Phosphatidylserine synthase (PSS) plays an essential role in glia and affects development as well as the maintenance of neuronal function. iScience: 24:102899. PMID: 34401677
  2. Mok JW, Chung HL, Choi KW (2020) Calx, a sodium/calcium exchanger, may affect lifespan in Drosophila melanogaster.microPublication Biology. PMID: 32550491
  3. Chung HL*, Mao X*, Wang H, Park Y, Marcogliese PC, Rosenfels JA, Burrage LC, Liu P, Murdock DR, Yamamoto S, Wangler MF, Undiagnosed Diseases Network, Chao HT, Long H, Feng L, Bacino CA, Bellen HJ#, Xiao B# (2020) De novo variants in CDK19 are associated with a new syndrome with intellectual disability and epileptic encephalopathy. American Journal of Human Genetics: 106:717-725. PMID: 32330417 *Contributed equally; #Co-corresponding
  4. Chung HL, Wangler MF, Marcogliese PC, Jo J, Ravenscroft TA, Zuo Z, Duraine L, Sadeghzadeh, S, Li-Kroeger D, Schmidt RE, Pestronk A, Rosenfeld JA, Burrage L, Herndon MJ, Chen S, Members of Undiagnosed Diseases Network, Shillington A, Vawter-Lee M, Hopkin R, Rodriguez-Smith J, Henrickson M, Lee B, Moser AB, Jones RO, Watkins P, Yoo T, Mar S, Choi M, Bucelli RC, Yamamoto S, Lee HK, Prada CE, Chae JH, Vogel TP, and Bellen, HJ(2020). Loss- or gain-of-function mutations in ACOX1 cause axonal loss via different mechanisms. Neuron: 106:589-606. PMID: 32169171

2019

  1. Link N, Chung HL, Jolly A, Withers M, Tepe B, Arenkiel BR, Shah PS, Krogan NJ, Aydin H, Geckinli BB, Tos T, Isikay S, Tuysuz B, Mochida GH, Thomas AX, Clark RD, Mirzaa GM, Lupski JR, Bellen HJ (2019) Mutations in ANKLE2, a ZIKA virus target, disrupt an asymmetric cell division pathway in Drosophila neuroblasts to cause microcephaly.Developmental Cell: 51:713-729. PMID: 31735666
  2. Ansar M*, Chung HL*, Al-Otaibi A, Elagabani MN, Ravenscoft TA, Paracha SA, Scholz R, Abdel Magid T, Sarwar MT, Shah SF, Qaisar AA, Makrythanasis P, Marcoglises PC, Kamsteeg EJ, Falconnet E, Ranza E, Santoni FA, Aldhalaan H, Al-Asmari A, Faqeih EA, Ahmed J, Kornau HC, , Bellen HJ#, Antonarakis SE# (2019) Biallelic variants in IQSEC1 cause intellectual disability, developmental delay, and short stature.American Journal of Human Genetics: 105:907-920. PMID: 31607425 *Contributed equally; #Co-corresponding
  3. Kanca O, Zirin J, Garcia-Marques J, Knight SM, Yang-Zhou D, Amador G, Chung HL, Zuo Z, Ma L, He Y, Lin WW, Fang Y, Ge M, Yamamoto S, Schulze KL, Hu Y, Spradling AC, Mohr SE, Perrimon N, Bellen HJ. (2019) An efficient CRISPR-based strategy to insert small and large fragments of DNA using short homology arms. eLife: 8:e51539. PMID: 31674908

2018

  1. Ansar M*, Chung HL*, Taylor RL, Nazir A, Imtiaz S, Sarwar MT, Manousopoulou A, Makrythanasis P, Saeed S, Falconnet E, Guipponi M, Pournaras CJ, Ansari MA, Ranza E, Santoni FA, Ahmed J, Shah I, Gul K, Black GC, Bellen HJ#, Antonarakis SE# (2018) Bi-allelic loss-of-function variants in DNMBP cause infantile cataracts. American Journal of Human Genetics: 103:568-578. PMID: 30290152 *Contributed equally; #Co-corresponding
  2. Ansar M*, Chung HL*, Waryah YM, Makrythanasis P, Falconnet E, Rao AR, Guipponi M, Narsani AK, Fingerhut R, Santoni FA, Ranza E, Waryah AM, Bellen HJ#, Antonarakis SE# (2018) Visual impairment and progressive phthisis bulbi caused by recessive pathogenic variant in MARK3. Human Molecular Genetics: 27:2703-2711. PMID: 29771303 *Contributed equally; #Co-corresponding
  3. Marcogliese PC, Shashi V, Spillmann RC, Stong N, Rosenfeld JA, Koenig MK, Martínez-Agosto JA, Herzog M, Chen AH, Dickson PI, Lin HJ, Vera MU, Salamon N, Graham JM Jr, Ortiz D, Infante E, Steyaert W, Dermaut B, Poppe B, Chung HL, Zuo Z, Lee PT, Kanca O, Xia F, Yang Y, Smith EC, Jasien J, Kansagra S, Spiridigliozzi G, El-Dairi M, Lark R, Riley K, Koeberl DD, Golden-Grant K; Program for Undiagnosed Diseases (UD-PrOZA); Undiagnosed Diseases Network, Yamamoto S, Wangler MF, Mirzaa G, Hemelsoet D, Lee B, Nelson SF, Goldstein DB, Bellen HJ, Pena LDM (2018) IRF2BPL is associated with neurological phenotypes.American Journal of Human Genetics 103:245-260. PMID: 30193138

2016

  1. Chung HL, Augustine GJ, Choi KW (2016) Drosophila Schip1 links Expanded and Tao-1 to regulate Hippo signaling.Developmental Cell: 36(5): p.511-24. PMID: 26954546
  2. Chung HL and Choi KW (2016) Schip1, a new upstream regulator of Hippo signaling. Cell Cycle. Invited review,15(16): p.2097-2098. PMID: 27246165

2024

  1. Liao JZ*, Chung HL*, Shih C., Wong KKL., Dutta D, Nil Z, Burns CG, Kanca O, Park YJ, Zuo Z, Marcogliese PC, Sew K, Bellen HJ# and Verheyen EM#. (2024) Cdk8/CDK19 promotes mitochondrial fission through Drp1 phosphorylation and can phenotypically suppress pink1 deficiency in Drosophila. Nature Communications,15, 3326. PMID: 38637532 *Contributed equally; #Co-corresponding
  2. Tanaka T, Chung HL. (2024) Exploiting fly models to investigate rare human neurological disorders. Neural Regeneration Research DOI: 0.4103/NRR.NRR-D-23-01847

2023

  1. Chung HL*,#, Ye Q*, Park YJ, Zuo Z, Kanca O, Tattikota SG, Lanza IR, Oglesbee D, Perrimon N, Lee HK#, Bellen HJ# (2023). Very-long-chain fatty acids induce glial-derived sphingosine-1-phosphate synthesis, secretion, and neuroinflammation. Cell metabolism.PMID: 37084732 *Contributed equally; #Co-corresponding
  2. Ma M*, Zhang X*, Zheng Y, Lu S, Pan X, Mao X, Pan H, Chung HL, Wang H, Guo H#, Bellen HJ#(2023). The fly homolog of SUPT16H, a gene associated with neurodevelopmental disorders, is required in a cell-autonomous fashion for cell survival. Human Molecular Genetics. PMID: 36255738 *Contributed equally; #Co-corresponding

2022

  1. Chung HL, Rump P, Glassford MR, Fatih J, Basal A, Marcogliese PC, Rapp M, Fock JM, Kamsteeg E, Lupski JR, Larson A, Haninbal MC, Bellen HJ#, Harel T# (2022). De novovariants in EMC1 lead to neurodevelopmental delay and cerebellar degeneration and affect glial function in Drosophila. Human Molecular Genetics. PMID: 35234901 #Co-corresponding
  2. Lu S, Hernan R, Marcogliese PC, Huang Y, Gertler TS, Akcaboy M, Liu S, Chung HL, Pan X, Sun X, Oguz M, Oztoprak U, de Baaij JHF, Ivanisevic J, McGinnis E, Sacoto MJG, Chung WK#, Bellen HJ# (2022) Loss of function variants in TIAM1 are associated with developmental delay, intellectual disability and seizures. American Journal of Human Genetics: 25;S0002-9297(22)00051-9. PMID: 35240055 #Co-corresponding
  3. Marcogliese PC*, Deal SM*, Andrews J*, Harnish JM*, Bhavana VH, Graves HK, Jangnam S, Luo Xi, Liu N, Bei D, Hull B, Lee P, Pan H, Brady C, Chao H, Chung HL, Haelterman NA, Kanca O, Manivannan SN, Rosetti LZ, Gerard A, Schwaibold EMC, Guerrini R, Vetro A, England E, Murali CN, Barakat TS, Dooren MF, Wilke M, Slegtenhorst MV, Sabatier I, Chatron N, Brownstein CA, Madden JA, Agrawal PB, Keller R, Pavinato L, Brusco A, Rosenfeld JA, Marom R, Wangler MF#, Yamamoto S# (2022) Drosophila functional screening of de novo variants in autism uncovers deleterious variants and facilitates the discovery of rare neurodevelopmental diseases. Cell reports: 15;38(11):110517. PMID: 35294868 *Contributed equally; #Co-corresponding
  4. Marcogliese PC*,#, Dutta D*, Sinha-Ray S, Dang NDP, Zuo Z, Wang Y, Lu D, Fazal F, Ravenscroft TA, Chung HL, Kanca O, Wan J, Douine ED, Pena LDM, Yamamoto S, Nelson SF, Might M, Meyer KC, Yeo NC, Bellen HJ# (2022). Loss of IRF2BPL impairs neuronal maintenance through excess Wnt signaling. Science Advances: 21;8(3):eabl5613. PMID: 35044823 *Contributed equally; #Co-corresponding

2021

  1. Manivannan SN, Roovers J, Smal N, Meyers CT, Turkdogan D, Roelens F, Kanca O, Chung HL, Scholz T, Herrmann K, Bierhals T, Mefford H, de Jonghe P, Yamamoto S, Weckhuysen S, Bellen HJ (2021) De novo FZR1 loss-of-function variants cause developmental and epileptic encephalopathies including Myoclonic Atonic Epilepsy. Brain. PMID: 34788397
  2. Manor J, Chung HL, Bhagwat P, Wangle MF (2021) ABCD1 and X-linked adrenoleukodystrophy: A disease with a markedly variable phenotype showing conserved neurobiology in animal models. Journal of Neuroscience Research. review article. PMID: 34716609

2020

  1. Park YJ, Kim S, Shim HP, Park JH, Lee G, Kim TY, Jo MC, Kwon AY, Lee M, Chung HL, Bellen HJ, Kwon SH, Jeon SH (2020) Phosphatidylserine synthase (PSS) plays an essential role in glia and affects development as well as the maintenance of neuronal function. iScience: 24:102899. PMID: 34401677
  2. Mok JW, Chung HL, Choi KW (2020) Calx, a sodium/calcium exchanger, may affect lifespan in Drosophila melanogaster.microPublication Biology. PMID: 32550491
  3. Chung HL*, Mao X*, Wang H, Park Y, Marcogliese PC, Rosenfels JA, Burrage LC, Liu P, Murdock DR, Yamamoto S, Wangler MF, Undiagnosed Diseases Network, Chao HT, Long H, Feng L, Bacino CA, Bellen HJ#, Xiao B# (2020) De novo variants in CDK19 are associated with a new syndrome with intellectual disability and epileptic encephalopathy. American Journal of Human Genetics: 106:717-725. PMID: 32330417 *Contributed equally; #Co-corresponding
  4. Chung HL, Wangler MF, Marcogliese PC, Jo J, Ravenscroft TA, Zuo Z, Duraine L, Sadeghzadeh, S, Li-Kroeger D, Schmidt RE, Pestronk A, Rosenfeld JA, Burrage L, Herndon MJ, Chen S, Members of Undiagnosed Diseases Network, Shillington A, Vawter-Lee M, Hopkin R, Rodriguez-Smith J, Henrickson M, Lee B, Moser AB, Jones RO, Watkins P, Yoo T, Mar S, Choi M, Bucelli RC, Yamamoto S, Lee HK, Prada CE, Chae JH, Vogel TP, and Bellen, HJ(2020). Loss- or gain-of-function mutations in ACOX1 cause axonal loss via different mechanisms. Neuron: 106:589-606. PMID: 32169171

2019

  1. Link N, Chung HL, Jolly A, Withers M, Tepe B, Arenkiel BR, Shah PS, Krogan NJ, Aydin H, Geckinli BB, Tos T, Isikay S, Tuysuz B, Mochida GH, Thomas AX, Clark RD, Mirzaa GM, Lupski JR, Bellen HJ (2019) Mutations in ANKLE2, a ZIKA virus target, disrupt an asymmetric cell division pathway in Drosophila neuroblasts to cause microcephaly.Developmental Cell: 51:713-729. PMID: 31735666
  2. Ansar M*, Chung HL*, Al-Otaibi A, Elagabani MN, Ravenscoft TA, Paracha SA, Scholz R, Abdel Magid T, Sarwar MT, Shah SF, Qaisar AA, Makrythanasis P, Marcoglises PC, Kamsteeg EJ, Falconnet E, Ranza E, Santoni FA, Aldhalaan H, Al-Asmari A, Faqeih EA, Ahmed J, Kornau HC, , Bellen HJ#, Antonarakis SE# (2019) Biallelic variants in IQSEC1 cause intellectual disability, developmental delay, and short stature.American Journal of Human Genetics: 105:907-920. PMID: 31607425 *Contributed equally; #Co-corresponding
  3. Kanca O, Zirin J, Garcia-Marques J, Knight SM, Yang-Zhou D, Amador G, Chung HL, Zuo Z, Ma L, He Y, Lin WW, Fang Y, Ge M, Yamamoto S, Schulze KL, Hu Y, Spradling AC, Mohr SE, Perrimon N, Bellen HJ. (2019) An efficient CRISPR-based strategy to insert small and large fragments of DNA using short homology arms. eLife: 8:e51539. PMID: 31674908

2018

  1. Ansar M*, Chung HL*, Taylor RL, Nazir A, Imtiaz S, Sarwar MT, Manousopoulou A, Makrythanasis P, Saeed S, Falconnet E, Guipponi M, Pournaras CJ, Ansari MA, Ranza E, Santoni FA, Ahmed J, Shah I, Gul K, Black GC, Bellen HJ#, Antonarakis SE# (2018) Bi-allelic loss-of-function variants in DNMBP cause infantile cataracts. American Journal of Human Genetics: 103:568-578. PMID: 30290152 *Contributed equally; #Co-corresponding
  2. Ansar M*, Chung HL*, Waryah YM, Makrythanasis P, Falconnet E, Rao AR, Guipponi M, Narsani AK, Fingerhut R, Santoni FA, Ranza E, Waryah AM, Bellen HJ#, Antonarakis SE# (2018) Visual impairment and progressive phthisis bulbi caused by recessive pathogenic variant in MARK3. Human Molecular Genetics: 27:2703-2711. PMID: 29771303 *Contributed equally; #Co-corresponding
  3. Marcogliese PC, Shashi V, Spillmann RC, Stong N, Rosenfeld JA, Koenig MK, Martínez-Agosto JA, Herzog M, Chen AH, Dickson PI, Lin HJ, Vera MU, Salamon N, Graham JM Jr, Ortiz D, Infante E, Steyaert W, Dermaut B, Poppe B, Chung HL, Zuo Z, Lee PT, Kanca O, Xia F, Yang Y, Smith EC, Jasien J, Kansagra S, Spiridigliozzi G, El-Dairi M, Lark R, Riley K, Koeberl DD, Golden-Grant K; Program for Undiagnosed Diseases (UD-PrOZA); Undiagnosed Diseases Network, Yamamoto S, Wangler MF, Mirzaa G, Hemelsoet D, Lee B, Nelson SF, Goldstein DB, Bellen HJ, Pena LDM (2018) IRF2BPL is associated with neurological phenotypes.American Journal of Human Genetics 103:245-260. PMID: 30193138

2016

  1. Chung HL, Augustine GJ, Choi KW (2016) Drosophila Schip1 links Expanded and Tao-1 to regulate Hippo signaling.Developmental Cell: 36(5): p.511-24. PMID: 26954546
  2. Chung HL and Choi KW (2016) Schip1, a new upstream regulator of Hippo signaling. Cell Cycle. Invited review,15(16): p.2097-2098. PMID: 27246165
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